"Biosynthesis of new lactose esters via lipases. Characteristics of their physicochemical and anti-cancer properties."

Maciej Guzik, PhD

Project Leader

Wojciech Snoch, MSc

PhD student

Biocatalysys

Bio-catalysts – in our case enzymes – have already started displacing the traditional chemical counterparts in industrial production. Green catalysts offer environmentally friendly synthesis and production of only one ultra-pure product.  Our research idea is to employ enzymes from the family of lipases, which in living organisms, including human beings, digest fats into fatty acids and glycerin, or, in other words, perform reaction of fats hydrolysis. For many years lipases have been used to produce biofuels. They are added to washing powders to aid in the removal of greasy stains. In certain conditions, these enzymes can perform a reverse reaction to hydrolysis – they are able to stick together a molecule of an organic acid to another, containing alcohol group (for example glycerin, ethanol or a sugar), thus creating a new ester bond.

Acnowlegments

PROJECT SONATA ""Biosynthesis of new lactose esters via lipases. Characteristics of their physicochemical and anti-cancer properties."" is sponsored by the National Science Centre Poland 

From whey to anticancer drugs

In Poland we have a large and well-functioning dairy industry, which unfortunately generates huge amounts of liquid wastes – whey. Its surplus, which is still rich in lactose, is in most of the cases underutilized and is used as a feedstock for cattle. Thinking about these locally generated waste streams, and having in mind sustainable development of our country, we have chosen lactose to make sugar esters using lipases. We will test a range of enzymes originating from a variety of organisms thanks to which we will get several differently build esters made from lactose and monomers coming from bioplastics.

Theoretical and experimental
investigation of reaction mechanism

One may ask – why would we look into making such exotic molecules built from whey lactose and polyhydroxyalkanoates monomers? It is common knowledge that cancerous cells munch on sugars more greedily than normal cells do and our new compounds are built from a sugar. In addition, scientists have shown that, once taken up by a cell, sugar esters completely mess up their energy production system. On top of that, the Irish research has shown that an addition of a PHA monomer to an anticancer drug largely improves the latter’s therapeutic effect. These facts provide quite an optimistic premise that we are on a right track to create not only a new drug to fight cancer, but also to equip the scientific society with methods for novel esters preparation and their characterization.

What do we do

Our aim is to combine the research potentials of Institute of Catalysis and Surface Chemistry and Institute of Plant Physiology in the field of biochemistry and biotechnology

Our Projects

Laboratory members aplly for new domestic and international projects in order to carry out increasingly advanced research

Join our team

We are open to scientists willing to cooperate on ongoing projects as well as those coming with their own scientific ideas

Contact us

If you are interested in research conducted in our laboratory or have any questions, please do not hesitate and feel free to contact us