Lider VII - "Novel functionalised biopolymers for medical applications"
Project aims at producing novel functionalised biopolymers for medical applications. Bacterial polyesters, polyhydroxyalkanoates (PHAs), will be modified by a biocatalytic esterification with antibiotics, steroids and nonsteroidal anti-inflammatory drugs.
Maciej Guzik, PhD
TechMatStrateg II - “Vegetable oil biorefining technology for the production of advanced composite materials”
Project for the development of biorefining technology for vegetable oils for advanced comoposite materials. The overall goal of the project is to create a demonstration line, biorefinery module for the production of a unique bacterial polymer line - PHAs.
Macej Guzik, PhD
OPUS 11 - “The mechanism of regioselective oxidative dehydrogenation of3-ketosteroids catalyzed by Δ1-cholest-4-en-3-one dehydrogenase from Sterolibacterium denitrificans”
The project aims at elucidation of the catalytic mechanism for 3-ketosteroid dehydrogenase from Sterolibacterium denitrificans and its structural characterization.
Professor Maciej Szaleniec
Beethoven Life FAEREACTION - “Structure and function of fumarate-adding glycyl radical enzymes: biochemistry, modeling and application”
This project aims at investigation of the biochemistry and reactions mechanisms of a class of novel enzymes which catalyse the radical-based addition of fumarate to a number of highly recalcitrant compounds, like hydrocarbons. These fumarate-adding enzymes (FAE) which form a subclass of the glycyl radical enzymes will be studies with combination of experimental and theoretical tools. Furhermore we intend to develop a new whole-cell biotransformation systems involving FAE.
Professor Maciej Szaleniec
Sonata - “Biosynthesis of new lactose esters via lipases. Characteristics of their physicochemical and anti-cancer properties.”
Why would we look into making such exotic molecules built from whey lactose and polyhydroxyalkanoates monomers? It is common knowledge that cancerous cells munch on sugars more greedily than normal cells do and our new compounds are built from a sugar. In addition, scientists have shown that, once taken up by a cell, sugar esters completely mess up their energy production system. On top of that, the Irish research has shown that an addition of a PHA monomer to an anticancer drug largely improves the latter’s therapeutic effect. These facts provide quite an optimistic premise that we are on a right track to create not only a new drug to fight cancer, but also to equip the scientific society with methods for novel esters preparation. and their characterization.